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You are here:Home » Antibodies » Abs to Smad Proteins » Anti -SMAD2 (HMAD-2, HSMAD2, JV18-1, Mad Protein Homolog Smad2, MADR2, MADH2, SMAD 2, MAD Homolog 2, Mad-Related Protein 2, JV18, Mother against DPP Homolog 2, Mothers against DPP Homolog 2, Sma- and Mad-Related Protein 2, SMAD Family Member 2)

Anti -SMAD2 (HMAD-2, HSMAD2, JV18-1, Mad Protein Homolog Smad2, MADR2, MADH2, SMAD 2, MAD
Homolog 2, Mad-Related Protein 2, JV18, Mother against DPP Homolog 2, Mothers against DPP
Homolog 2, Sma- and Mad-Related Protein 2, SMAD Family Member 2)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Purified E B IP IH
Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.
Catalog #171273
ApplicationsSuitable for use in ELISA, Western Blot, Immunoprecipitation and Immunohistochemistry. Other applications not tested.
Recommended DilutionWestern Blot: 1:2000
Immunohistochemistry (Formalin fixed paraffin embedded): 1:200
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG2b,k
Clone No14e31
HostMouse
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in HEPES, 0.15M sodium chloride, 0.01% BSA, 0.03% sodium azide, 50% glycerol.
PurityPurified
ImmunogenRecombinant protein corresponding to human SMAD2 expressed in E. coli (His-Smad2).
SpecificityRecognizes human SMAD2. Species Crossreactivity: mouse and rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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