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You are here:Home » Antibodies » Abs to Transcription Factors, Forkhead (FOX) » Anti -FOXP3 (JM2, AIID, DIETER, IPEX, MGC141961, MGC141963, PIDX, XPID, FOXP3delta7, forkhead box Protein P3, immune dysregulation, polyendocrinopathy, enteropathy, X-linked, immunodeficiency, polyendocrinopathy, enteropathy, X-linked, scurfin) (Biotin)

Anti -FOXP3 (JM2, AIID, DIETER, IPEX, MGC141961, MGC141963, PIDX, XPID, FOXP3delta7,
forkhead box Protein P3, immune dysregulation, polyendocrinopathy, enteropathy, X-linked,
immunodeficiency, polyendocrinopathy, enteropathy, X-linked, scurfin) (Biotin)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E IP IH FC IF
Recognizes a protein of 47-55kD, which is identified as FOXP3. Its precise epitope is not known, but it has been mapped to the N-terminal portion of the protein. The FOX family of transcription factors is a large group of proteins that share a common DNA binding domain termed a winged-helix or forkhead domain. During early development, FOXP1 and FOXP2 are expressed abundantly in the lung, with lower levels of expression in neural, intestinal and cardiovascular tissues, where they act as transcription repressors. FOXP1 is widely expressed in adult tissues, while neoplastic cells often exhibit a dramatic change in expression level or localization of FOXP1. Mutations in FOXP3 gene cause IPEX, a fatal, X-linked inherited disorder characterized by immune dysregulation. The FOXP3 protein is essential for normal immune homeostasis. Specifically, FOXP3 represses transcription through a DNA binding forkhead domain, thereby regulating T cell activation.
Catalog #172096-Biotin
ApplicationsSuitable for use in Immunofluorescence, Flow Cytometry, ELISA, Immunoprecipitation, Immunohistochemistry. Other applications not tested.
Recommended DilutionFlow Cytometry: 0.5-1ug/million cells
Immunofluorescence: 0.5-1ug/ml
Immunoprecipitation: 0.5-1µg/500ug protein lysate
Immunohistochemistry (Frozen): 0.5-1ug/ml for 30 minutes at RT
Optimal dilution for a specific application should be determined.
Positive ControlTonsil, lymph node or Breast carcinoma
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Note Applications are based on unconjugated antibody.
Clone TypeMonoclonal
IsotypeIgG1,k
Clone NoSPM579
HostMouse
ConcentrationAs reported
FormSupplied as a liquid in 10mM PBS. No preservative added. BSA-Free. Conjugated to Biotin.
PurityPurified by Protein A/G affinity chromatography.
ImmunogenFull-length human FOXP3 protein. Cellular Localization: Predominantly nuclear, some cytoplasmic
SpecificityRecognizes FOXP3. Species Crossreactivity: Human, Monkey and Mouse.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesJM2, AIID, DIETER, IPEX, MGC141961, MGC141963, PIDX, XPID, FOXP3delta7, forkhead box Protein P3, immune dysregulation, polyendocrinopathy, enteropathy, X-linked, immunodeficiency, polyendocrinopathy, enteropathy, X-linked, scurfin


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