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210372 Rabbit Anti-CYP19A1 (Cytochrome P450 19A1, ARO, ARO1, CPV1, CYAR, CYP19, MGC104309, P-450AROM)

Specifications
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Swiss Prot
P11511
Isotype
IgG
Grade
Affinity Purified
Applications
IHC IP WB
Crossreactivity
Hu Mo Rt
Gene ID
1588
Shipping Temp
Blue Ice
Storage Temp
-20°C

CYP19A1(Cytochrome P450 19A1) is also named as ARO1(aromatase), CYAR, CYP19, estrogen synthase and belongs to the cytochrome P450 family. It is a terminal enzyme which transforms irreversibly androgens into estrogens and it is present in the endoplasmic reticulum of numerous tissues(PMID:16406261). The gene encodes a protein with the molecular weight between 46kD and 69kD (PMID:8129748) and the protein can be glycosylated, but the level of glycosylation does not seem to be essential for CYP19A1 activity(PMID:12606587). Brain aromatase may be neuroprotective by increasing the local estrogen levels in injured neurons so that genetic variation in the brain aromatase gene may modify the risk for AD(PMID:16767510). This antibody is specific to CYP19A1.

Applications
Suitable for use in Western Blot, Immunoprecipitation, Immunohistochemistry. Other applications not tested.
Recommended Dilution
Western Blot: 1:500-1:2000 Immunohistochemistry: 1:50-1:200 Immunoprecipitation: 1:20-1:100 Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
Recombinant protein corresponding to human CYP19A1.
Form
Supplied as a liquid in PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Purity
Purified by affinity chromatography.
Specificity
Recognizes CYP19A1. Species Crossreactivity: human, mouse, rat
Conjugates
Pricing
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