Laminin Subunit beta-2, Laminin beta2, Laminin B1s Chain, Laminin-11 Subunit beta, Laminin-14 Subunit beta, Laminin-15 Subunit beta, Laminin-3 Subunit beta, Laminin-4 Subunit beta, Laminin-7 Subunit beta, Laminin-9 Subunit beta, S-laminin Subunit beta, S-LAM beta, LAMB2, LAMS

The Laminins comprise a growing family of disulfide-linked heterotrimers consisting of three genetically distinct polypeptide chains, designated alpha, beta and y. A major component of the basal lamina, Laminins play a crucial role in providing a scaffolding upon which tissues are assembled and which serves as a physical barrier separating specialized tissues. During embryogenesis and early development, cells migrate along basement membranes, which are required for the polarization of cells. The beta-2 laminin chain plays a role in melanoma spread, promoting tumor migration along the abluminal surface of vessel, a phenomenon which has been termed extra-vascular migratory metastasis.