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Specifications

Clone Host Grade Applications Monoclonal Mouse B

Catalog #	A0000-20
Application(s)
	Western Blot (1:1'000)
	A20 is a zinc finger protein that renders cells resistant to apoptosis. A20-deficient mice develop severe inflammation and are hyper-responsive to LPS. S.M. O'Reilly & P.N. Moynagh have shown that full length A20 inhibits activation of NF-kB and AP-1 by TLR4 [1]. A20 associates with A20-binding inhibitor of NF-kB (ABIN)-1 and -2 [2-4], which interfere with NF-kB activation upstream of the IKK complex.
CAS Number	n/a
Clone Type	Monoclonal
Isotype	IgG1
Clone No	6D88
Host	Mouse
Source	Human
Form	Supplied as a liquid in PBS containing 0.02% sodium azide.
Immunogen	Zinc finger domain corresponding to aa 375-537 of human A20.
Specificity	Recognizes human A20.
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.