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You are here:Home » Biochemicals » MB-Enzyme Substrates » ALLM, Calpain Inhibitor II, Ac-LLM-CHO (N-Acetyl-Leu-Leu-Methional)

ALLM, Calpain Inhibitor II, Ac-LLM-CHO (N-Acetyl-Leu-Leu-Methional)

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Specifications

A cell-permeable inhibitor of calpain 1 (Ki =120nM) and calpain 2 (Ki =230nM). Also potently inhibits cathepsin B (Ki =100nM), and cathepsin L (Ki=0.6nM). Shown to induce caspase-dependent apoptosis in human acute lymphoblastic leukemia and non-Hodgkin’s Lymphoma cells.
Catalog #A0002-90
SequenceN-Acetyl-Leu-Leu-Methional
SolubilityDMSO (25mg/ml) or EtOH (25mg/ml)
Molecular Weight~401.57
Storage and StabilityLyophilized powder may be stored at -20°C. Reconstitute with sterile buffer or dH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
CAS Number136632-32-1
Molecular FormulaC H N O S
Molecular Weight~401.57
Purity~95% (HPLC)
ConcentrationNot determined
FormSupplied as a powder.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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