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ALLM, Calpain Inhibitor II, Ac-LLM-CHO (N-Acetyl-Leu-Leu-Methional)
ALLM, Calpain Inhibitor II, Ac-LLM-CHO (N-Acetyl-Leu-Leu-Methional)
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| A cell-permeable inhibitor of calpain 1 (Ki =120nM) and calpain 2 (Ki =230nM). Also potently inhibits cathepsin B (Ki =100nM), and cathepsin L (Ki=0.6nM). Shown to induce caspase-dependent apoptosis in human acute lymphoblastic leukemia and non-Hodgkin’s Lymphoma cells. | | | Catalog # | A0002-90 | | Sequence | N-Acetyl-Leu-Leu-Methional | | Solubility | DMSO (25mg/ml) or EtOH (25mg/ml) | | Molecular Weight | ~401.57 | | Storage and Stability | Lyophilized powder may be stored at -20°C. Reconstitute with sterile buffer or dH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | 136632-32-1 | | Molecular Formula | C H N O S | | Molecular Weight | ~401.57 | | Purity | ~95% (HPLC) | | Concentration | Not determined | | Form | Supplied as a powder. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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