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You are here:Home » Antibodies » Abs to Multi Drug Resistance (MDR) » Anti -ABCA4 (Retinal-specific ATP-binding Cassette Transporter, ATP-binding Cassette Sub-family A Member 4, RIM ABC Transporter, RIM Protein, RmP, Stargardt Disease Protein, ABCR)

Anti -ABCA4 (Retinal-specific ATP-binding Cassette Transporter, ATP-binding Cassette
Sub-family A Member 4, RIM ABC Transporter, RIM Protein, RmP, Stargardt Disease Protein,
ABCR)

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Goat Affinity Purified E
In the visual cycle, acts as an inward-directed retinoid flipase, retinoid substrates imported by ABCA4 from the extracellular or intradiscal (rod) membrane surfaces to the cytoplasmic membrane surface are all-trans-retinaldehyde (ATR) and N-retinyl-phosphatidyl-ethanolamine (NR-PE). Once transported to the cytoplasmic surface, ATR is reduced to vitamin A by trans-retinol dehydrogenase (tRDH) and then transferred to the retinal pigment epithelium (RPE) where it is converted to 11-cis-retinal. May play a role in photoresponse, removing ATR/NR-PE from the extracellular photoreceptor surfaces during bleach recovery.
Catalog #A0004-02D3
ApplicationsSuitable for use in ELISA. Other applications not tested.
Recommended DilutionELISA: 1:8000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
HostGoat
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to C-KQQTESHDLPLHPR, from ABCA4, at C-terminal (NP_000341.2).
SpecificityRecognizes ABCA4. Species sequence homology: Canine and human.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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