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You are here:Home » Antibodies » Abs to Multi Drug Resistance (MDR) » Anti -ABC B5 (ATP Binding Cassette Sub-family B (MDR/TAP) Member 5, ATP-binding Cassette Sub-family B Member 5, ABCB 5, ABCB5, ABCB5alpha, ABCB5beta, EST422562, P-glycoprotein ABCB5)

Anti -ABC B5 (ATP Binding Cassette Sub-family B (MDR/TAP) Member 5, ATP-binding Cassette
Sub-family B Member 5, ABCB 5, ABCB5, ABCB5alpha, ABCB5beta, EST422562, P-glycoprotein
ABCB5)

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Goat Affinity Purified E B
ABCB5 (ATP-binding cassette, subfamily B [DR/TAP] member 5) is a 90kD (predicted MW) member of the human P-glycoprotein family of molecules. It is expressed by CD133+ pluripotent pigment stem cells, where it serves as a marker for cells that show a high incidence of polyploidy. Human ABCB5 is 812aa in length. It is possibly a five transmembrane protein with a 247aa N-terminal extracellular domain (ECD) aa1-247 and a 283aa C-terminal cytoplasmic region aa530-812. The ECD contains one ABC transporter aa2-177, while the cytoplasmic region contains a second ABC transporter aa570-808. There are two potential splice forms. One shows a seven aa substitution for aa125-812, while another possesses an alternative start site 445aa upstream of the standard site. Over aa141-247, human ABCB5 shares 64aa identity with mouse ABCB5.
Catalog #A0004-02Y
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionELISA: 1:128000
Western Blot: 0.03-0.1ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile 40-50% glycerol, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostGoat
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in Tris-saline, pH 7.3, 0.02% sodium azide, 0.5% BSA.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide, CQTQHRNTSKKAQ, corresponding to the internal region of ABCB5 (NP_848654.3).
SpecificityRecognizes human ABCB5 at ~80kD.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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