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Anti -ABC B5 (ATP Binding Cassette Sub-family B (MDR/TAP) Member 5, ATP-binding Cassette Sub-family B Member 5, ABCB 5, ABCB5, ABCB5alpha, ABCB5beta, EST422562, P-glycoprotein ABCB5)
Anti -ABC B5 (ATP Binding Cassette Sub-family B (MDR/TAP) Member 5, ATP-binding Cassette
Sub-family B Member 5, ABCB 5, ABCB5, ABCB5alpha, ABCB5beta, EST422562, P-glycoprotein
ABCB5)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Goat |
Affinity Purified |
B |
|
| ABCB5 (ATP-binding cassette, subfamily B [DR/TAP] member 5) is a 90kD (predicted MW) member of the human P-glycoprotein family of molecules. It is expressed by CD133+ pluripotent pigment stem cells, where it serves as a marker for cells that show a high incidence of polyploidy. Human ABCB5 is 812aa in length. It is possibly a five transmembrane protein with a 247aa N-terminal extracellular domain (ECD) aa1-247 and a 283aa C-terminal cytoplasmic region aa530-812. The ECD contains one ABC transporter aa2-177, while the cytoplasmic region contains a second ABC transporter aa570-808. There are two potential splice forms. One shows a seven aa substitution for aa125-812, while another possesses an alternative start site 445aa upstream of the standard site. Over aa141-247, human ABCB5 shares 64aa identity with mouse ABCB5. | | | Catalog # | A0004-02Y1 | | Applications | Suitable for use in Western Blot. Other applications not tested. | | Recommended Dilution | Western Blot: 0.03-0.1ug/ml | | Optimal dilutions to be determined by the researcher. | | Positive Control | lysates of A431 | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Goat | | Source | Human | | Concentration | ~0.5mg/ml | | Form | Supplied as a liquid in Tris saline, 0.02% sodium azide, pH7.3, 0.5% BSA. | | Purity | Purified by immunoaffinity chromatography. | | Immunogen | Synthetic peptide corresponding to QTQHRNTSKKAQ from the internal region of the protein sequence according to NP_848654.3. | | Specificity | Recognizes human ABCB5. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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