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You are here:Home » Antibodies » Abs to Multi Drug Resistance (MDR) » Anti -ABC E1 (ATP-binding Cassette (ABC) Transporter 1)

Anti -ABC E1 (ATP-binding Cassette (ABC) Transporter 1)

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Specifications

Clone Host Grade Applications
Polyclonal Goat Serum E B
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the OABP subfamily. Alternatively referred to as the RNase L inhibitor, this protein functions to block the activity of ribonuclease L. Activation of ribonuclease L leads to inhibition of protein synthesis in the 2-5A/RNase L system, the central pathway for viral interferon action. Two transcript variants encoding the same protein have been found for this gene.
Catalog #A0004-03A
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionELISA: 1:8000
Western Blot: 0.3-1ug/ml 70kD band observed in lysates of cell lines A431 (calculated MW of 67.6kDa according to NP_002931.1)
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20°C. Aliquots are stable for at least 3 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight67.6kD
Clone TypePolyclonal
IsotypeIgG
HostGoat
SourceHuman
Concentration0.5mg/ml
FormSupplied as a liquid in Tris-saline, pH 7.3. 0.5% BSA, 0.02% sodium azide.
PuritySerum
ImmunogenPeptide with sequence C-KLNSIKDVEQKK, from the C Terminus of the protein sequence according to NP_002931.1
SpecificitySpecies Crossreactivity
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesABCE1 RLI, OABP, ABC38, RNS4I, RNASEL1, RNASELI, ATP-binding cassette, sub-family E (OABP), member 1, RNase L inhibitor ,ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) inhibitory, -HP68


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