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You are here:Home » Antibodies » Abs to Multi Drug Resistance (MDR) » Anti -ABCE1 (ATP-binding Cassette Sub-family E Member 1, 2'-5'-oligoadenylate-binding Protein, HuHP68, RNase L Inhibitor, Ribonuclease 4 Inhibitor, RNS4I, RLI, RNASEL1, RNASELI, RNS4I, OK/SW-cl.40)

Anti -ABCE1 (ATP-binding Cassette Sub-family E Member 1, 2'-5'-oligoadenylate-binding
Protein, HuHP68, RNase L Inhibitor, Ribonuclease 4 Inhibitor, RNS4I, RLI, RNASEL1,
RNASELI, RNS4I, OK/SW-cl.40)

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Goat Affinity Purified E B
Antagonizes the binding of 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) by RNase L through direct interaction with RNase L and therefore inhibits its endoribonuclease activity. May play a central role in the regulation of mRNA turnover. Antagonizes the anti-viral effect of the interferon-regulated 2-5A/RNase L pathway. May act as a chaperone for post-translational events during HIV-1 capsid assembly.
Catalog #A0004-03F
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionELISA: 1:8000
Western Blot: 0.3-1ug/ml, observed in lysates of cell lines A431 on ~70kD bands
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
HostGoat
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to C-KLNSIKDVEQKK, from human ABCE1, at C-terminal (NP_002931.2, NP_001035809.1).
SpecificityRecognizes human ABCE1. Species sequence homology: Bovine, canine, mouse and rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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