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You are here:Home » Antibodies » Abs to Multi Drug Resistance (MDR) » Anti -ABCG1 (ATP-binding Cassette (ABC) Transporter 1)

Anti -ABCG1 (ATP-binding Cassette (ABC) Transporter 1)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E B
The ATP binding cassette (ABC) superfamily of membrane transporters is one of the largest protein classes known, and counts for numerous proteins involved in trafficking of biological molecules across membranes, host-defense mechanism to xenobiotics. The first known members were P-glycoprotein (P-gp) and multidrug resistant protein (MRP), cause multidrug resistance when transfected into drug-sensitive cells. In addition, increasing numbers of ABC proteins have recently been identified. The human ABCG1 (ABC, subfamily G, member 1) gene encodes a member of ABC superfamily that mediates the ATP-dependent translocation of variety of amphiphilic and lipophilic molecules. ABCG proteins were able to transport substances across cellular membranes and against concentration gradient they require an input of energy, which requires the hydrolysis of ATP, directly or indirectly.
ABCG1 a 678aa protein in human (chr 21q22.3), 666aa in mouse, predominantly expressed in many tissues, in the intracellular compartments mainly associated with endoplasmic reticulum and Golgi complex. It shows 26% sequence homology with ABCG2 protein. ABCG1 protein is involved in macrophage lipid homeostasis, an active member of macrophage lipid export complex.
Catalog #A0004-04M
ApplicationsSuitable for use in Western Blot and ELISA. Other applications not tested.
Recommended DilutionWestern Blot: 1-10ug/ml using ECL.
ELISA: 0.5-1ug/ml Use A0004-04M1 to coat ELISA plates at 1ug/ml.
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceMouse
Concentration~1mg/ml
FormSupplied as a liquid in PBS, pH 7.2, 0.1% BSA.
PurityPurified by immunoaffinity chromatography.
ImmunogenA synthetic peptide corresponding to 14-aa from mouse ABCG1 (KLH). Epitope: C-terminus, Extracellular.
SpecificityRecognizes mouse ABC G1. Species sequence homology: rat-100%, human-92%.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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