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You are here:Home » Antibodies » Abs to Multi Drug Resistance (MDR) » Anti -ABCG3 (ATP-binding Cassette (ABC) Transporter 3)

Anti -ABCG3 (ATP-binding Cassette (ABC) Transporter 3)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E B
The ATP binding cassette (ABC) superfamily of membrane transporters is one of the largest protein classes known, and counts for numerous proteins involved in trafficking of biological molecules across membranes, host-defense mechanism to xenobiotics. The first known members were P-glycoprotein (P-gp) and multidrug resistant protein (MRP), cause multidrug resistance when transfected into drug-sensitive cells. In addition, increasing numbers of ABC proteins have recently been identified.
ABCG3 protein is a 650aa protein in mouse, highly expressed in the thymus and spleen. It seems to have defective ATP binding region, which suggests the ABCG3 protein may not bind or hydrolyze ATP. Therefore, it has to dimerize with another subunit to form a functional transporter. It is unique among ABC genes in not having several highly conserved residues in the A and C domains of NBF. ABCG3 is the most closely related to ABCG2 with 54% homology overall, 64% in the NBF and 50% in the TM region.
Catalog #A0004-04U
ApplicationsSuitable for use in Western Blot and ELISA. Other applications not tested.
Recommended DilutionsWestern Blot: 1-10ug/ml (ECL)
ELISA: 0.5-1ug/ml; Use control peptide (Cat #A0004-04U1) to coat ELISA plates at 1ug/ml.
Optimal dilutions to be deermined by the researcher.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceMouse
Concentration~1mg/ml (after reconstitution)
FormSupplied as a lyophilized powder from PBS, 0.1% BSA. Reconstitute with 100ul sterile PBS.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to 14aa near the C terminal, extracellular domain of mouse ABCG3, conjugated to KLH (Accession #Q8BKI5). Species Sequence Homology: rat - 100%.
SpecificityRecognizes mouse ABCG3.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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