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You are here:Home » Molecular Biology » MB-Peptides » ATP Binding Cassette subfamily G, Member 5, Control Peptide (ABCG5, Sterolin-1)

ATP Binding Cassette subfamily G, Member 5, Control Peptide (ABCG5, Sterolin-1)

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Specifications

Control peptide for A0004-05C, polyclonal antibody to ABCG5.
Catalog #A0004-05D
The ATP binding cassette (ABC) superfamily of membrane transporters is one of the largest protein classes known, and counts for numerous proteins involved in trafficking of biological molecules across membranes, host-defense mechanism to xenobiotics. The first known members were Pglycoprotein (P-gp) and multidrug resistant protein (MRP), cause multidrug resistance when transfected into drugsensitive cells. In addition, increasing numbers of ABC proteins have recently been identified. The human ABCG1 (ABC, subfamily G, member 1) gene encodes a member of ABC superfamily that mediates the ATP-dependent translocation of variety of amphiphilic and lipophilic molecules. ABCG proteins were able to transport substances across cellular membranes and against concentration gradient they require an input of energy, which requires the hydrolysis of ATP, directly or indirectly.
ABCG5 gene product a 651aa residue in human, and 652aa each in rat and mouse, plays an important role in the selective transport of cholesterol in and out of the enterocytes and in the selective sterol excretion by liver into bile. Strongly expressed in liver, intestine and colon. Defects in ABCG5 results increased intestinal absorption of sterols and decreased biliary excretion of dietary sterols into bile; the condition is referred as sitosterolemia.
SourceSynthetic peptide corresponding to 14aa of human ABCG5, N-terminal.
Molecular Weight~3kD
ApplicationsSuitable for use in ELISA and Antibody Blocking. Not suitable for Western Blot. Other applications not tested.
Recommended DilutionELISA: 1ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing.. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight~3kD
SourceSynthetic peptide
PurityPurified
Concentration~1mg/ml
FormSupplied as a lyophilized pwder from PBS, pH7.5.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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