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You are here:Home » Molecular Biology » MB-Infectious Disease » ABIN-1, Recombinant, Human (TNIP1, TNFAIP3 Interacting Protein 1, HIV-1 Nef-interacting Protein, Nef-associated Factor 1, Naf1, Nip40-1, Virion-associated Nuclear Shuttling Protein, VAN, hVAN, KIAA0113, NAF1)

ABIN-1, Recombinant, Human (TNIP1, TNFAIP3 Interacting Protein 1, HIV-1 Nef-interacting
Protein, Nef-associated Factor 1, Naf1, Nip40-1, Virion-associated Nuclear Shuttling
Protein, VAN, hVAN, KIAA0113, NAF1)

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Specifications

TNIP1 (TNFAIP3-interacting protein 1) has been shown to interacts with zinc finger protein A20/TNFAIP3 and inhibits TNF-induced NF-kappa-B-dependent gene expression by interfering with an RIP- or TRAF2-mediated transactivation signal. In addition, interacts with HIV-1 matrix protein and is packaged into virions and overexpression can inhibit viral replication. It may regulate matrix nuclear localization, both nuclear import of PIC (Preintegration complex) and export of GAG polyprotein and viral genomic RNA during virion production.
Catalog #A0004-74H
SourceRecombinant corresponding to aa94-530 of human TNIP1 protein, fused to His-tag at N-terminus, expressed in E.coli.
AA SequenceMGSSHHHHHH SSGLVPRGSH MSNVTASPTA PACPSDKPAP VQKPPSSGTS SEFEVVTPEE QNSPESSSHA NAMALGPLPR EDGNLMLHLQ RLETTLSVCA EEPDHGQLFT HLGRMALEFN RLASKVHKNE QRTSILQTLC EQLRKENEAL KAKLDKGLEQ RDQAAERLRE ENLELKKLLM SNGNKEGASG RPGSPKMEGT GKKAVAGQQQ ASVTAGKVPE VVALGAAEKK VKMLEQQRSE LLEVNKQWDQ HFRSMKQQYE QKITELRQKL ADLQKQVTDL EAEREQKQRD FDRKLLLAKS KIEMEETDKE QLTAEAKELR QKVKYLQDQL SPLTRQREYQ EKEIQRLNKA LEEALSIQTP PSSPPTAFGS PEGAGALLRK QELVTQNELL KQQVKIFEED FQRERSDRER MNEEKEELKK QVEKLQAQVT LSNAQLKAFK DEEKAREALR QQKRKAKA
Molecular Weight 51.8kD (458aa) confirmed by MALDI-TOF
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight51.8kD
SourceE.coli
Purity~75% (SDS-PAGE).
Concentration~0.25mg/ml
FormSupplied as a liquid in 20mM Tris-HCl, pH7.5, 20% glycerol, 5mM DTT, 200mM sodium chloride.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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