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You are here:Home » Antibodies » Antibodies-Transcription Factors » Anti -ABIN-1 (A-20 binding Inhibitor of Nuclear Factor-kappaB (NF-kB) Activation)

Anti -ABIN-1 (A-20 binding Inhibitor of Nuclear Factor-kappaB (NF-kB) Activation)


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Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E B IP
A20-binding inhibitor of NFkB activation (ABIN-1) is involved in NFkB-dependent gene expression and plays an important role in numerous cellular processes including stress responses, inflammation and cell proliferation. ABIN-1 increases cell surface CD4 (T4) antigen expression, and it interacts with HIV-1 matrix protein and is packaged into virions. Overexpression of ABIN-1can .inhibit viral replication. ABIN-1 may also regulate matrix nuclear localization, both nuclear import of PIC (Preintegration complex) and export of GAG polyprotein and viral genomic RNA during virion production. ABIN-1 is strongly expressed in peripheral blood lymphocytes, spleen and skeletal muscle, and is weakly expressed in the brain.
Catalog #A0004-75A
ApplicationsSuitable for use in ELISA, Immunoprecipitation and Western Blot. Other applications have not been tested.
Recommended DilutionsELISA (Immunogen): 0.1-1ug/ml
Immunoprecipitatio (Human): 7-10ug/test
Western Blot (Human): 1-3ug/ml
Optimal dilutions to be determined by the researcher.
Positive ControlHEK-293 cell lysate.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
Clone No6A2
FormSupplied as a liquid in PBS, pH 7.4, 0.1% sodium azide.
PurityPurified by Protein A chromatography.
ImmunogenSynthetic peptide corresponding to the N-terminal region of the human, mouse and rat ABIN-1 protein.
SpecificityRecognizes the ~80kD human ABIN-1 protein. Bands of unknown origin at ~180kD and >250kD were observed in Western Blots using HEK-293 cell lysates. Species Sequence Homology: mouse and rat 100%.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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