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You are here:Home » Antibodies » Abs to Coenzyme A » Anti -AcCoA Carboxylase, Phosphorylated (Ser79) (ACC, Acetyl Coenzyme A Carboxylase)

Anti -AcCoA Carboxylase, Phosphorylated (Ser79) (ACC, Acetyl Coenzyme A Carboxylase)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E B IP IH
Acetyl-CoA carboxylase (ACC) catalyzes the pivotal step of the fatty acid synthesis pathway. The 265kD ACC-alpha is the predominant isoform in liver, adipocyte and mammary gland, while the 280kD ACC-beta is the major isoform in skeletal muscle and heart. Phosphorylation by AMPK at serine 79, or by PKA at serine 1200, inhibits the enzymatic activity of ACC. Recent research indicates that ACC is a potential target of antiobesity drugs.
Catalog #A0225-05
ApplicationsSuitable for use in ELISA, Western Blot, Immunoprecipitation and Immunohistochemistry. Other applications not tested.
Recommended DilutionsWestern Blot: 1:1000
Immunoprecipitation: 1:100
Immunohistochemistry (Paraffin): 1:600, with heating in citrate buffer used as antigen retrieval.
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceRat
ConcentrationNot Determined
FormSupplied as a liquid in 10mM sodium HEPES, pH 7.5, 150mM sodium chloride, 0.1mg/ml BSA, 50% glycerol.
PurityPurified by Protein A and immunoaffinity chromatography.
ImmunogenSynthetic phosphopeptide corresponding to residues surrounding Ser79 of rat ACC.
SpecificityRecognizes endogenous levels of rat Ser79 phosphorylated ACC. Recognizes both ACCalpha and ACCbeta in humans. MW of Antigen
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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