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Specifications

Clone Host Grade Applications Monoclonal Mouse Affinity Purified E B

Neuronal acetylcholine receptor is composed of alpha and beta subunits. The Alpha-4 subunit can be combined to beta-2 or beta-4 to give rise to functional receptors. Upon binding of acetylcholine, the acetylcholine receptor responds by undergoing an extensive change of conformation affecting all its subunits and lead to the opening of an ion-conducting channel across the plasma membrane. Neuronal acetylcholine receptor subunit alpha-4 is a transmembrane protein that localises to the cell junction, synapse and post synaptic cell membrane. It belongs to the ligand-gated ionic channel family. Abnormalities in the CHRNA4 gene cause autosomal dominant nocturnal frontal lobe epilepsy type 1. This disease is characterised by clusters of motor seizures during sleep.
Catalog #	A0526-35G
Applications	Suitable for use in ELISA, Western Blot. Other applications not tested.
Recommended Dilution	Optimal dilutions to be determined by the researcher.
Storage and Stability	Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile 40-50% glycerol, ddH2O. Reconstituted product is stable for 12 months at -20°C. Aliquot and store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
CAS Number	n/a
Clone Type	Monoclonal
Isotype	IgG
Clone No	9G305
Host	Mouse
Source	Human
Concentration	As reported
Form	Supplied as a lyophilized powder in PBS, pH7.2. Reconstitute with 100ul sterile ddH2O.
Purity	Purified by affinity chromatography.
Immunogen	Partial recombinant protein of human neuronal acetylcholine receptor subunit alpha-4 (aa29-128) with a GST tag.
Specificity	Recognizes human neuronal acetylcholine receptor subunit alpha-4.
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.