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You are here:Home » Antibodies » Abs to Receptors, Cholinergic » Anti -Acetylcholine Receptor (Muscarinic 1)

Anti -Acetylcholine Receptor (Muscarinic 1)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B
Acetylcholine receptors (AChRs) mediate synaptic transmission at the neuromuscular junction. The channel-linked AChR that mediates rapid, excitatory actions of acetylcholine is called nicotinic AChR (nAChR) because it can be activated by nicotine. The non-channel linked AChR that mediates the slow actions of acetylcholine, which can be either inhibitory or excitatory, is called muscarinic AChR (mAChR) because it can be activated by muscarine. The mAChRs are present in neurons of the central and peripheral nervous systems, cardiac and smooth muscle and various exocrine glands. There are 5 subtypes (m1-m5) of the receptor that have a tissue specific pattern of expression. The m1 receptor is localized primarily in brain tissue.
Catalog #A0526-40
ApplicationsSuitable for use in Western Blot. Not suitable for use in Immunohistochemistry. Other applications have not been tested.
Recommended DilutionsWestern Blot: 2ug/ml. Detects an ~64kD protein representing recombinant mouse m1AChR.
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
Concentration~1mg/ml
FormSupplied as a liquid in PBS, 1mg/ml BSA, 0.05% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenFusion protein corresponding to aa269-320 from the human Acetylcholine Receptor (Muscarinic 1). Species Sequence Homology: mouse, rat and bovine
SpecificityRecognizes the human Acetylcholine Receptor (Muscarinic 1). Species Crossreactivity: mouse
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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