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You are here:Home » Antibodies » Abs to Enzymes, Acetylcholinesterase » Anti -Acetylcholinesterase YT blood group (Acetylcholine acetylhydrolase, ACHE, precursor, ARACHE, N-ACHE-YT)

Anti -Acetylcholinesterase YT blood group (Acetylcholine acetylhydrolase, ACHE, precursor,
ARACHE, N-ACHE-YT)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified IP IH
Cholinergic neurotransmission occurs in motor, autonomic and central nervous synapses and requires very rapid inactivation of its transmitter, acetylcholine (ACh). Acetylcholinesterase (AChE) rapidly hydrolyzes ACh to acetate and choline, thereby inactivating it. AChE is found in the neuromuscular junction anchored to the basal lamina which runs between the nerve terminal and muscle membrane. AChE is also found outside the nervous and neuromuscular system in blood, lymph, germ and liver cells suggesting a role for AChE not related to cholinergic transmission. Another less specific cholinesterase, butyrylcholinesterase (BChE), seems to contribute to the regulation of the ACh concentration in the synaptic cleft.
Catalog #A0526-42F
ApplicationsSuitable for use in Immunohistochemistry and Immunoprecipitation. Not recommended for Western Blot. Other applications have not been tested.
Recommended DilutionImmunohistochemistry: 1:1000
Optimal dilution to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG2b
Clone No6D90
HostMouse
SourceRat
ConcentrationNot determined
FormSupplied as a liquid in PBS, 1mg/ml BSA, 0.05% sodium azide.
PurityPurified by Protein A affinity chromatography.
ImmunogenPurified rat brain AChE (acetylcholinesterase)
SpecificityRecognizes rat Acetylcholinesterase YT blood group. Reacts with both the soluble and membrane-associated AChE. Immunohistochemical staining of AChE in rat brain results in staining of nerve fibers and terminals. Species crossreactivity: guinea pig, rabbit, feline. Does not cross-react with BChE (butyrylcholinesterase).
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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