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You are here:Home » Antibodies » Antibodies-Apoptosis » Anti -Acinus (AAE7, ACN1, AC NON-UTILIZING 1, ACYL-ACTIVATING ENZYME 7, AT3G16910.1, Apoptotic Chromatin condensation inducer in nucleus)

Apoptotic Chromatin condensation inducer in nucleus)


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Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E B
Chromatin condensation and nuclear fragmentation (CCNF) is the hallmark of apoptosis. CCNF is triggered by the activation of members of caspase family, caspase activated DNase (CAD/DFF40), and several novel proteins including AIF and CIDE (1). A new inducer of chromatin condensation was recently identified and designated Acinus (for apoptotic chromatin condensation inducer in the nucleus). Acinus is cleaved by caspase-3 and an additional unknown protease generating a small active peptide p17, which causes chromatin condensation in vitro when it is added to purified nuclei. Acinus also induces apoptotic chromatin condensation in cells. Acinus is ubiquitously expressed. Three different spliced forms of Acinus have been identified in human and mouse and designated AcinusL, AcinusS and AcinusSí (2).
Catalog #A0600-02
ApplicationsSuitable for use in ELISA, Western Blotting. Other applications not tested.
Recommended DilutionWestern Blotting: 0.5-1ug/ul
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%). Freeze at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
FormSupplied as a liquid, 100ug in 200ul of PBS, 0.02% sodium azide.
PurityImmunoaffinity chromatography purified IgG
ImmunogenRaised against a peptide (DTSENRPENDVPEPP) corresponding to amino acids 775 to 789 of human AcinusL, 48 to 62 of human AcinusSí, or 17 to 31 of human AcinusS, which differ from those of mouse Acinus by one amino acid (2).
SpecificityRecognizes human Acinus. An approximate 220kD band can be detected. Species crossreactivity: Mouse.
Important NoteThis product is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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