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Anti -Acinus (Apoptotic Chromatin Condensation Inducer in the Nucleus, ACN, Apoptotic Chromatin Condensation Inducer 1, ACIN1, DKFZp667N107, fSAP152, KIAA0670)
Anti -Acinus (Apoptotic Chromatin Condensation Inducer in the Nucleus, ACN, Apoptotic
Chromatin Condensation Inducer 1, ACIN1, DKFZp667N107, fSAP152, KIAA0670)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
B IC IF |
|
| Acinus (apoptotic chromatin condensation inducer in the nucleus) is a caspase substrate that has been implicated in nuclear changes during apoptosis (1). Chromatin condensation and DNA fragmentation are both nuclear morphological features associated with apoptosis. Acinus is expressed in different isoforms (L, S, S') most likely generated by alternative splicing (1). During apoptosis Acinus is cleaved by caspase-3 to generate a 23 kDa fragment that was reported to induce chromatin condensation (1). Acinus has been identified to be a component of the spliceosome complex, ASAP, suggesting a role in pre-mRNA processing (2-4). Down regulation of Acinus by RNA interference inhibits cell growth (5). This study also found that loss of Acinus inhibits DNA fragmentation but not chromatin condensation during apoptosis. | | | Catalog # | A0600-02A | | Applications | Suitable for use in Immunofluorescence, Western Blot and Immunocytochemistry. Other applications not tested. | | Recommended Dilution | Immunofluorescence: 1:100 | | Western Blot: 1:1000 | | Immunocytochemistry: 1:100 | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Human | | Concentration | As reported | | Form | Supplied as a liquid in 10mM sodium HEPES pH 7.5, 150mM NaCl, 0.1mg/ml BSA, 50% glycerol. | | Purity | Purified by Protein A and peptide affinity chromatography. | | Immunogen | Synthetic peptide corresponding to residues surrounding Ala835 of Acinus. | | Specificity | Recognizes endogenous levels of human total Acinus protein. Recognizes L, S and S' isoforms. Species Crossreactivity: monkey, mouse, rat. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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