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You are here:Home » Antibodies » Abs to Protein Kinases » Anti -ACK1, phosphorylated (Tyr518) (Tyrosine Kinase Non-receptor Protein 2, Activated CDC42 Kinase 1, ACK-1, TNK2) (AP)

Anti -ACK1, phosphorylated (Tyr518) (Tyrosine Kinase Non-receptor Protein 2, Activated
CDC42 Kinase 1, ACK-1, TNK2) (AP)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E Gel
ACK1 is a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47aa C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway.
Catalog #A0650-01C-AP
ApplicationsSuitable for use in ELISA and Dot Blot. Other applications not tested.
Recommended DilutionELISA: 1:1,000
Dot Blot: 1:500
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Do not freeze alkaline phosphatase conjugates which could result in a substantial loss of enzymatic activity. Light sensitive. Aliquots are stable for at least 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in PBS, pH 7.2. Contains ~0.09% sodium azide. Conjugated to Alkaline Phosphatase.
PurityPurified by Protein A affinity chromatography.
ImmunogenSynthetic phosphopeptide corresponding to amino acid residues surrounding Tyr518 of human ACK1 (KLH).
SpecificityRecognizes human ACK1 when phosphorylated at Tyr518.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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