Anti -Aconitase 1 (ACO1, ACONS, IREB1, IREBP, IREBP1, IRP1, Aconitate Hydratase, Citrate
Hydro-lyase, Ferritin Repressor Protein, Iron Regulatory Protein 1, Iron-responsive
Element Binding Protein 1)
Pricing
For pricing information, USA customers sign in. Outside USA? Please contact your distributor for pricing. Specifications
| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Purified |
B |
|
| Aconitase 1, also known as iron regulatory element binding protein 1 (IREB1), is a cytosolic protein which binds to iron-responsive elements (IREs). IREs are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. The iron-induced binding to the IRE results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degrading transferrin receptor mRNA. Thus, IREB1 plays a central role in cellular iron homeostasis. It was also shown to have aconitase activity, and hence grouped with the aconitase family of enzymes. | | | Catalog # | A0660-01E | | Applications | Suitable for use in Western Blot. Other applications not tested. | | Recommended Dilution | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, 11c7entrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Host | Rabbit | | Source | Human | | Concentration | As reported | | Form | Supplied as a liquid in PBS, pH 7.2. | | Purity | Purified. | | Immunogen | ACO1 (NP_002188.1, 1-889aa) full-length human protein. | | Specificity | Recognizes human ACO1. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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Download Specifications for Anti -Aconitase 1 (ACO1, ACONS, IREB1, IREBP, IREBP1, IRP1, Aconitate Hydratase, Citrate Hydro-lyase, Ferritin Repressor Protein, Iron Regulatory Protein 1, Iron-responsive Element Binding Protein 1) |
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