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You are here:Home » Antibodies » Abs to Proteins » Anti -Aconitase 1 (ACO1, ACONS, IREB1, IREBP, IREBP1, IRP1, Aconitate Hydratase, Citrate Hydro-lyase, Ferritin Repressor Protein, Iron Regulatory Protein 1, Iron-responsive Element Binding Protein 1)

Anti -Aconitase 1 (ACO1, ACONS, IREB1, IREBP, IREBP1, IRP1, Aconitate Hydratase, Citrate
Hydro-lyase, Ferritin Repressor Protein, Iron Regulatory Protein 1, Iron-responsive
Element Binding Protein 1)

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Purified B
Aconitase 1, also known as iron regulatory element binding protein 1 (IREB1), is a cytosolic protein which binds to iron-responsive elements (IREs). IREs are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. The iron-induced binding to the IRE results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degrading transferrin receptor mRNA. Thus, IREB1 plays a central role in cellular iron homeostasis. It was also shown to have aconitase activity, and hence grouped with the aconitase family of enzymes.
Catalog #A0660-01E
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, 11c7entrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
HostRabbit
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in PBS, pH 7.2.
PurityPurified.
ImmunogenACO1 (NP_002188.1, 1-889aa) full-length human protein.
SpecificityRecognizes human ACO1.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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