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You are here:Home » Antibodies » Abs to Transcription Factors » Anti -ACT (Activator of cAMP Responsive Element Modulator (CREM) in Testis, Activator of CREM in Testis, dJ393D12.2, Four and a Half LIM Domains Protein 5, FHL5, FHL-5 Protein, FLJ33049, KIAA0776)

Anti -ACT (Activator of cAMP Responsive Element Modulator (CREM) in Testis, Activator of
CREM in Testis, dJ393D12.2, Four and a Half LIM Domains Protein 5, FHL5, FHL-5 Protein,
FLJ33049, KIAA0776)

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B
FHL proteins are tissue specific cofactors of CREB and CREM and participate in regulation of various physiological processes. These proteins are characterized by the presence of 4 LIM domains and a LIM-half domain at the N-terminus. ACT, a 33kD protein, is a novel member of this family. It is specifically expressed in male testis and consists of a central activation domain. It is coordinately expressed with CREM and plays a vital role in spermatogenesis. It binds specifically to CREM and powerfully stimulates its transcriptional activation, essential for differentiation of spermatids into mature spermatozoa. It activates CREM in a phosphorylation- and CBP-independent manner. Protein-protein interactions with a Kinesin KIF17B regulate ACT activity in mouse.
Catalog #A0750-06C
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 1:500-1:1000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in PBS, 0.02% sodium azide.
PurityPurified by Protein G affinity chromatography.
ImmunogenSynthetic peptide corresponding to the N-terminus of ACT.
SpecificityRecognizes human ACT.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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