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You are here:Home » Antibodies » Abs to Actin Related Proteins » Anti -Actin, Muscle Specific

Anti -Actin, Muscle Specific


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Clone Host Grade Applications
Monoclonal Mouse Ascites IH
Actins are highly conserved proteins which participate in a wide variety of cellular functions in eucaryotes including muscle contraction, amoeboid movement, cytokinesis, and mitotic division. Humans have six actin genes; two striated muscle types or sarcomeric (alpha-skeletal and alpha-cardiac), two smooth muscle types and two cytoskeletal forms (beta and gamma-types). The cytoplasmic beta and gamma actins are coexpressed in mammalian non-muscle cells, where it functions to control cell structure and motility. The two smooth muscle actins are expressed in smooth muscle and the sarcomeric actins, alpha-skeletal actin and alpha-cardiac actin are expressed in adult skeletal muscle and adult heart muscle respectively, regulating contractile potentials for these cells. It has been reported that actin is hyperphosphorylated in primary breast tumors. It has also been shown that actin dysfunction leads to certain types of heart failure.
Catalog #A0759-08F1
ApplicationsSuitable for use in Immunohistochemistry. Other applications not tested.
Recommended DilutionImmunohistochemistry (paraffin): 1:25-1:50
Optimal dilutions to be determined by the researcher.
Positive ControlSkeletal muscle
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
Clone No11E4+11E400
ConcentrationNot determined.
FormSupplied as a liquid, 0.05% sodium azide.
ImmunogenN-terminal decapeptide of alpha-smooth muscle actin for 11E4 and purified rabbit striated muscle actin for 11E400. Cellular Localization: Cytoplasmic.
SpecificityRecognizes rabbit Actin, pan. Species Crossreactivity: guinea pig, bovine, human, mouse, rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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