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You are here:Home » Antibodies » Antibodies-Actin Related Proteins » Anti -Actin, Muscle Specific

Anti -Actin, Muscle Specific


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Clone Host Grade Applications
Monoclonal Mouse Affinity Purified IH IF
Actin is a semi-flexible polymer found as a part of the cytoskeleton of cells in higher biological organisms. It is a highly conserved protein which participates in a wide variety of cellular functions in eucaryotes including muscle contraction, amoeboid movement, cytokinesis, and mitotic division. Actin protein as a polymer without attached proteins is called filamentous actin (F-actin), while the globular actin monomers are called G-actin. Humans have six actin genes; two striated muscle types or sarcomeric (alpha-skeletal and alpha-cardiac), two smooth muscle types ands two cytoskeletal forms (beta and gamma-types). Alpha-actin is found in muscle cells where it plays an important role in contracting the cell. Whereas beta-actin is localized in the front of moving cells and gamma-actin forms stress fibers. The cytoplasmic beta and gamma actins are coexpressed in mammalian non-muscle cells, while the two smooth muscle actins are coexpressed only in smooth muscle with their relative amounts varying in different smooth muscle types. Similarly the alpha-skeletal actin is thought to be the only actin expressed in adult skeletal muscle, and alpha-cardiac actin is thought to be the only actin expressed in adult heart muscle.
Catalog #A0760-22F
ApplicationsSuitable for use in Immunofluorescence and Immunohistochemistry. Other applications not tested.
Recommended DilutionImmunohistochemistry (Formalin fixed paraffin embedded): 20ug/ml
Optimal dilutions to be determined by the researcher.
Positive Control Muscle or sarcoma
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
Clone NoMSA06
FormSupplied as a liquid in 10mM PBS, pH 7.4, 0.2% BSA, 0.09% sodium azide.
PurityPurified by Protein G affinity chromatography.
ImmunogenPurified actin
SpecificityRecognizes human muscle Actin. Species sequence homology: Bovine, canine, equine, mouse, porcine, rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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