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You are here:Home » Antibodies » Abs to Actin Related Proteins » Anti -Actinin, alpha

Anti -Actinin, alpha

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Ascites B IP IH IF
Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene.
Catalog #A0762
ApplicationsSuitable for use in Western Blot, Immunoprecipitation, Immunofluorescence and Immunohistochemistry. Other applications have not been tested.
Recommended DilutionWestern Blot:~100kD (SDS reducing gels).
Immunofluorescence, Immunohistochemistry: Methanol fixed cells
Note: For extensive dilution, protein containing or other stabilizing medium should be used.
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG1
Clone No2Q1094
HostMouse
SourceHuman
ConcentrationNot determined
FormSupplied as a liquid.
PurityAscites
ImmunogenHuman platelet protein.
SpecificityRecognizes human alpha-actinin. Recognizes an epitope in the N-terminal region of alpha-actinin, probably between aa1-24.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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