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You are here:Home » Antibodies » Abs to Transcription Factors » Anti -Activating Transcription Factor 2, phosphorylated, Thr71 (ATF2, CREB P1)

Anti -Activating Transcription Factor 2, phosphorylated, Thr71 (ATF2, CREB P1)

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Specifications

Clone Host Grade Applications
Monoclonal Rabbit Supernatant B IP IC
ATF-2 (activating transcription factor-2, CRE-BP1) is a transcription factor that binds the cAMP response element (CRE) and AP-1 response element and is abundantly expressed in the brain. Various forms of cellular stress, including genotoxic agents, inflammatory cytokines, and UV irradiation, stimulate the transcriptional activity of ATF-2 (2). SAPK and p38 MAPK can activate, in response to cellular stress, ATF-2 by phosphorylating this protein at Thr69 and Thr71. Mutations of these sites result in the loss of stress-induced transcription by ATF-2 (2-4).
Catalog #A0855-43F
ApplicationsSuitable for use in Western Blotting, Immunoprecipitation, Immunocytochemistry. Other applications not tested.
Recommended DilutionWestern Blotting: 1:10,000
Immunocytochemistry: 1:100
Immunoprecipitation: 1:40
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Freeze at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Manufactured incorporating RabMAb® technology under Epitomics US patents, No 5,675,063 and 7,429,487, owned by Abcam.
Clone TypeMonoclonal
IsotypeIgG
Clone No6k9
HostRabbit
SourceHuman
FormSupplied as a liquid
PuritySupernatant
ImmunogenA synthetic phospho-peptide corresponding to residues surrounding Thr71 of human ATF-2
SpecificityRecognizes human ATF-2. Only detects ATF-2 phosphorylated on Threonine 71.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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