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You are here:Home » Antibodies » Abs to Transcription Factors » Anti -Activating Transcription Factor 2, phosphorylated (Thr71) (ATF2, cAMP Response Element Binding Protein 2, CRE BP1, CREB 2, CREB2, CREBP1, HB 16, HB16, MGC111558, mXBP, TREB 7, TREB7)

Anti -Activating Transcription Factor 2, phosphorylated (Thr71) (ATF2, cAMP Response
Element Binding Protein 2, CRE BP1, CREB 2, CREB2, CREBP1, HB 16, HB16, MGC111558, mXBP,
TREB 7, TREB7)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified B
ATF-2 is a member of the group of bZip transcription factors. Heterodimer formation between members of the bZip group is common and is believed to add diversity to the cis-acting elements at which binding of the dimers is directed. Specifically, ATF-2 may dimerize with c-Jun, as occurs in response to E1a, and in so doing shift the binding preference of c-Jun toward ATF/CRE sites (1-3). Deletion analysis has indicated that the N-terminal region of ATF-2 containing threonine at residues 69 and 71 are essential for this purpose. These threonine residues are phosphorylated by JNK/SAPK for transcriptional activation.
Catalog #A0855-43H
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 2ug/ml
Optimal dilutions to be determined by the researcher.
Positive Control TNF-a treated HeLa (1 hr)
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG1
Clone No8J183
HostMouse
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in PBS, containing 0.2% gelatin and 0.05% sodium azide
PurityPurified by affinity chromatography
ImmunogenSynthetic peptide containing phosphorylated threonine at position 71 of human ATF-2
SpecificityRecognizes human ATF2 phosphorylated at Thr71
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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