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You are here:Home » Antibodies » Abs to Transcription Factors » Anti -Activating Transcription Factor 2, phosphorylated (Ser490/498) (ATF2, cAMP Response Element Binding Protein 2, CRE BP1, CREB 2, CREB2, CREBP1, HB 16, HB16, MGC111558, mXBP, TREB 7, TREB7)

Anti -Activating Transcription Factor 2, phosphorylated (Ser490/498) (ATF2, cAMP Response
Element Binding Protein 2, CRE BP1, CREB 2, CREB2, CREBP1, HB 16, HB16, MGC111558, mXBP,
TREB 7, TREB7)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Serum B IH Gel
The activating transcription factor ATF2 (also called CRE-BP1) binds to both AP-1 and CRE DNA response elements and is a member of the ATF/CREB family of leucine zipper proteins. ATF2 has been implicated in the transcriptional regulation of a number of genes including cytokines, cell cycle control and apoptosis. Various forms of cellular stress, including inflammatory cytokines and UV irradiation, stimulate the transcriptional activity of ATF2. Stress induced ATF-dependent transcription is dependent on phosphorylation of ATF. Serine 490 and serine 498 are novel phosphorylation sites on ATF that have recently been identified. In addition, ATF2 is particularly abundant in the brain and the ATF2 family of transcription factors is considered an important substrate of signals upstream of the activation of genes associated with neuronal growth and differentiation. ATF expression has also been linked to the depression in humans.
Catalog #A0855-43S
ApplicationsSuitable for use in Dot Blot, Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionDot Blot: 1:1000
Western Blot: 1:1000
Immunohistochemistry: 1:1000
Note: Antibody dilutions and tissue load should be based on tissue type and expected
phosphorylation state expected expression level.
Optimal dilutions to be determined by the researcher.
Cellular Localization Nuclear
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
HostRabbit
SourceHuman
ConcentrationNot determined
FormSupplied as a liquid (serum)
PuritySerum
ImmunogenSynthetic phosphopeptide corresponding to amino acids residues surrounding the phospho Ser490/498 of human ATF2
SpecificitySpecific for ~74kDa human ATF2 protein phosphorylated at Ser490/498. The antibody also recognizes the phosphorylated ~54kDa splice form of ATF2
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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