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Anti -ATF4 (Activating Transcription Factor 4, Tax-responsive Enhancer Element B67, Cyclic AMP-dependent Transcription Factor ATF-4, cAMP-dependent Transcription Factor ATF-4, Cyclic AMP-responsive Element-binding Protein 2, CREB-2, cAMP-responsive Element-bind
Anti -ATF4 (Activating Transcription Factor 4, Tax-responsive Enhancer Element B67, Cyclic
AMP-dependent Transcription Factor ATF-4, cAMP-dependent Transcription Factor ATF-4,
Cyclic AMP-responsive Element-binding Protein 2, CREB-2, cAMP-responsive Element-bind
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Goat |
Affinity Purified |
E |
|
| ATF4 encodes a cAMP response element (CRE) binding protein called CREB-2 which acts as a transcriptional activator. The protein contains a COOH-terminal leucine-zipper motif and an adjacent basic domain. The protein is expressed ubiquitously in human brain and umbilical vein endothelial cell. The protein binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I. The protein is localized in the 22q13.1 region of human chromosome. Two pseudogenes are located on the X chromsome at q28 in a region containing a large inverted duplication. ATF4 negatively regulates transcription from the cAMP response element. The protein also acts as a critical regulator of osteoblast differentiation and function. Lack of ATF4 phosphorylation by RSK2 may contribute to the skeletal phenotype of CLS. | | | Catalog # | A0855-69L | | Applications | Suitable for use in ELISA. Other applications not tested. | | Recommended Dilution | ELISA: 1:100-1:1000 | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Goat | | Source | Human | | Concentration | ~0.5mg/ml | | Form | Supplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide. | | Purity | Purified by immunoaffinity chromatography. | | Immunogen | Synthetic peptide corresponding to aa339-350 (EEVRKARGKKRV) of human ATF4. | | Specificity | Recognizes human ATF4. Species Crossreactivity | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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