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You are here:Home » Antibodies » Abs to Transcription Factors » Anti -ATF4 (Activating Transcription Factor 4, Tax-responsive Enhancer Element B67, Cyclic AMP-dependent Transcription Factor ATF-4, cAMP-dependent Transcription Factor ATF-4, Cyclic AMP-responsive Element-binding Protein 2, CREB-2, cAMP-responsive Element-bind

Anti -ATF4 (Activating Transcription Factor 4, Tax-responsive Enhancer Element B67, Cyclic
AMP-dependent Transcription Factor ATF-4, cAMP-dependent Transcription Factor ATF-4,
Cyclic AMP-responsive Element-binding Protein 2, CREB-2, cAMP-responsive Element-bind

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Specifications

Clone Host Grade Applications
Polyclonal Goat Affinity Purified E
ATF4 encodes a cAMP response element (CRE) binding protein called CREB-2 which acts as a transcriptional activator. The protein contains a COOH-terminal leucine-zipper motif and an adjacent basic domain. The protein is expressed ubiquitously in human brain and umbilical vein endothelial cell. The protein binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I. The protein is localized in the 22q13.1 region of human chromosome. Two pseudogenes are located on the X chromsome at q28 in a region containing a large inverted duplication. ATF4 negatively regulates transcription from the cAMP response element. The protein also acts as a critical regulator of osteoblast differentiation and function. Lack of ATF4 phosphorylation by RSK2 may contribute to the skeletal phenotype of CLS.
Catalog #A0855-69L
ApplicationsSuitable for use in ELISA. Other applications not tested.
Recommended DilutionELISA: 1:100-1:1000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostGoat
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to aa339-350 (EEVRKARGKKRV) of human ATF4.
SpecificityRecognizes human ATF4. Species Crossreactivity
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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