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You are here:Home » Antibodies » Abs to Transcription Factors » Anti -ATF4 (Activating Transcription Factor 4, Tax-responsive Enhancer Element B67, Cyclic AMP-dependent Transcription Factor ATF-4, cAMP-dependent Transcription Factor ATF-4, Cyclic AMP-responsive Element-binding Protein 2, CREB-2, cAMP-responsive Element-bind

Anti -ATF4 (Activating Transcription Factor 4, Tax-responsive Enhancer Element B67, Cyclic
AMP-dependent Transcription Factor ATF-4, cAMP-dependent Transcription Factor ATF-4,
Cyclic AMP-responsive Element-binding Protein 2, CREB-2, cAMP-responsive Element-bind

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Purified E B IH
Activating transcription factor 4 (ATF4) was initially identified as a widely expressed mammalian DNA binding protein that could bind tax-responsive enhancer element within the LTR of HTLV-1. In a later study, it was isolated and characterized as cAMP-response element binding protein 2 (CREB-2). However, this sequence (M86842) has no sequence similarity with the CREB2 gene. ATF4 belongs to a family of DNA-binding proteins including the AP-1 family of transcription factors and cAMP-response element binding proteins (CREBs) and CREB-like proteins. ATF4 gene encodes a 351aa protein that contains a leucine zipper structure (protein-protein interaction) located C-terminal to a stretch of basic amino acids (DNA binding), a characteristic of its family of transcription factors. ATF4 was shown to bind and negatively regulate transcription from the cAMP response element. It is widely expressed in human tissues suggesting that it may be involved in regulating transcription in a wide variety of cell types.
Catalog #A0855-69Q
ApplicationsSuitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionELISA: 1:20,000
Western Blot: 1:500
Immunohistochemistry (Formalin fixed paraffin embedded): 2ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in PBS, pH 7.4.
PurityPurified
ImmunogenSynthetic peptide corresponding to human ATF4.
SpecificityRecognizes human ATF4. Species sequence homology: mouse and rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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