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Anti -AICDA, CT (Dr.92887, Aicda Protein)
Anti -AICDA, CT (Dr.92887, Aicda Protein)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
E B |
|
| Activation-induced cytidine deaminase (AICDA) was initially discovered as a homolog of the apolipoprotein B RNA-editing cytidine deaminase 1 (APOBEC1) that showed cytidine deaminase properties in stimulated B cell lines. It is necessary for somatic hypermutation and class switch recombination (CSR) in B cells, but inappropriate or dysregulated expression AICDA is often found in tumors and B cell neoplasms. Although it is structurally and functionally similar to the APOBEC proteins, it appears unlikely that AICDA deaminates dC to dU residues in HIV cDNA as does APOBEC3G. In bony fish such as zebrafish, the AICDA homologue also showed a similar function with mammalians, in which AICDA protein can mediate CSR. | | | Catalog # | A0855-76 | | Applications | Suitable for use in ELISA and Western Blot. Other applications not tested. | | Recommended Dilution | ELISA: 1:5000-1:20,000 | | Western Blot: 1:500-1:1000 | | Optimal dilutions to be determined by the researcher. | | Control Peptide | A0855-76D | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Zebrafish | | Concentration | As reported | | Form | Supplied as a liquid in 40mM MOPS, pH 7.5, 0.1% BSA, 0.05% sodium azide, 50% glycerol. | | Purity | Purified by immunoaffinity chromatography. | | Immunogen | Synthetic peptide corresponding to the C-terminal region of zebrafish AICDA. | | Specificity | Recognizes zebrafish AICDA. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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