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You are here:Home » Antibodies » Abs to Heat Shock Proteins » Anti -Activator of 90kD Heat Shock Protein ATPase Homolog 1 (Activator of Heat Shock 90kDa Protein ATPase Homolog 1, AHA1, AHSA1, C14orf3, HSPC322, p38) (Azide Free)

Anti -Activator of 90kD Heat Shock Protein ATPase Homolog 1 (Activator of Heat Shock 90kDa
Protein ATPase Homolog 1, AHA1, AHSA1, C14orf3, HSPC322, p38) (Azide Free)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Purified E B IP
The MAPK (mitogen activated protein kinase) comprises a family of ubiquitous proline-directed, protein-serine/threonine kinases which signal transduction pathways that control intracellular events including acute responses to hormones and major developmental changes in organisms (1). This super family consists of stress activated protein kinases (SAPKs); extracellular
signal-regulated kinases (ERKs); and p38 kinases, each of which forms a separate pathway (2). The kinase members that populate each pathway are sequentially activated by phosphorylation. Upon activation, p38 MAPK/SAPK2 translocates into the nucleus where it phosphorylates
one or more nuclear substrates, effecting transcriptional changes and other cellular processes involved in cell growth, division, differentiation, inflammation, and death (3). Specifically p38 always acts as a pro-apoptotic factor with its activation leading to the release of cytochrome c from mitochondria and cleavage of caspase 3 and its downstream effector, PARP (4). p38 MAPK is activated by a variety of chemical stress inducers including hydrogen peroxide, heavy metals, anisomycin, sodium salicylate, LPS, and biological stress signals such as tumor necrosis factor, interleukin-1, ionizing and UV irradiation, hyperosmotic stress and chemotherapeutic
drugs (5). As a result, p38 alpha has been widely validated as a target for inflammatory disease including rheumatoid arthritis, COPD and psoriasis (6) and has also been implicated in cancer, CNS and diabetes (7).
Catalog #A0855-77B
ApplicationsSuitable for use in ELISA, Western Blot and Immunoprecipitation. Other applications not tested.
Recommended DilutionWestern Blot: 1:1000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG1
Clone No10F679
HostMouse
Concentration~1mg/ml
FormSupplied as a liquid in PBS, 50% glycerol.
PurityPurified by ammonium sulfate precipitation.
ImmunogenFull length recombinant protein expressed in E.coli.
SpecificityRecognizes p38. Species Crossreactivity: No known cross-reactivity with other related human kinases rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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