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You are here:Home » Antibodies » Abs to Activin Receptors » Anti -ACVRL1 (Serine/Threonine-protein Kinase Receptor R3, SKR3, Activin Receptor-like Kinase 1, ALK-1, TGF-B Superfamily Receptor Type I, TSR-I, ACVRLK1, ALK1)

Anti -ACVRL1 (Serine/Threonine-protein Kinase Receptor R3, SKR3, Activin Receptor-like
Kinase 1, ALK-1, TGF-B Superfamily Receptor Type I, TSR-I, ACVRLK1, ALK1)

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Goat Affinity Purified E B
ACVRL1 is a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. This protein, sometimes termed ALK1, shares similar domain structures with other closely related ALK or activin receptor-like kinase proteins that form a subfamily of receptor serine/threonine kinases. Mutations in this gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2.
Catalog #A0855-91H
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionELISA: 1:32,000
Western Blot: 1-3ug/ml, observed in lysates of cell line MCF7 on ~60kD bands
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
HostGoat
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to C-KISNSPEKPKVIQ, from human ACVRL1, at C-terminal (NP_000011.2, NP_001070869.1).
SpecificityRecognizes human ACVRL1.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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