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You are here:Home » Antibodies » Abs to Activin Receptors » Anti -Activin Receptor Type-2B (ACVR2B, Activin Receptor Type IIB, ACTR-IIB) (Biotin)

Anti -Activin Receptor Type-2B (ACVR2B, Activin Receptor Type IIB, ACTR-IIB) (Biotin)

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Specifications

Clone Host Grade Applications
Polyclonal Goat Affinity Purified B
Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. ACVR2B (activin A type IIB receptor)displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor.
Catalog #A0856-10B
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 0.1-0.2ug/ml; Detection limit for rhACVR2B is ~5ng/lane under non-reducing and reducing conditions.
Optimal dilutions to be determined by the researcher.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile buffer. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostGoat
SourceHuman
Concentration~50ug/ml
FormSupplied as a lyophilized powder in 0.2um sterile-filtered solution in PBS and BSA. Labeled with Biotin. Reconstitute with 1ml of sterile Tris-buffered saline, pH 7.3 (20mM Trizma base, 150mM sodium chloride), 0.1% BSA.
PurityPurified by immunoaffinity chromatography.
ImmunogenNS0-derived, recombinant human Activin RIIB extracellular domain.
SpecificityRecognizes human Activin Receptor Type-2B, extracellular domain.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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