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Specifications

Clone Host Grade Applications Monoclonal Mouse Affinity Purified E B

Members of the TGF-beta superfamily exert their biological effects by binding to heteromeric complexes of a type I and a type II serine-threonine kinase receptor, both of which are essential for signal transduction. Activin receptor type IIB is a type II receptor that mediates multiple signals for transforming growth factor-beta (TGF-beta) family members, including Activin, Nodal, BMP-7, GDF-1, GDF-3, Myostatin (GDF-8), and GDF-11. Through alternative mRNA splicing, multiple ActR-IIB isoforms can also be generated.
Catalog #	A0856-10C
Applications	Suitable for use in ELISA and Western Blot. Other applications not tested.
Recommended Dilution	Direct ELISA: 0.5-1.0ug/ml. The detection limit for recombinant human Activin RIIB is ~2ng/well.
	Western Blot: 1-2ug/ml. The detection limit for recombinant human Activin RIIB is ~20ng/lane under reducing and non-reducing conditions.
	Optimal dilutions to be determined by the researcher.
Storage and Stability	Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
CAS Number	n/a
Clone Type	Monoclonal
Isotype	IgG1
Clone No	9H21
Host	Mouse
Source	Human
Concentration	~0.5mg/ml (after reconstitution)
Form	Supplied as a lyophilized powder from PBS, 5% trehalose. Reconstitute with 1ml sterile PBS.
Purity	Purified by Protein G affinity chromatography.
Immunogen	Recombinant protein corresponding to the extracellular domain of human Activin RIIB, expressed in NSO cells.
Specificity	Recognizes recombinant human Activin RIIB. Shows ~5% crossreactivity with recombinant human Activin RIIA.
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.