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You are here:Home » Antibodies » Abs to Cancer Markers » Anti -AIB 1 (Amplified in Breast Cancer-1)

Anti -AIB 1 (Amplified in Breast Cancer-1)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B
Steroid and thyroid hormones and retinoic acid regulate a complex array of gene expression activity via intracellular receptor transcription factors belonging to the ligand-dependent nuclear receptor superfamily. Adding to the complexity of function of these transcription factors are associated proteins known as coactivators and corepressors which, as their names suggest, enhance or depress transcription activity of the nuclear receptor with which they associate. Amplified in breast cancer-1 (AIB-1), is a member of a growing family of transcriptional coactivator proteins which includes steroid receptor coactivator-1 (SRC-1) and glucocorticoid receptor interacting protein-1 (GRIP1). AIB1:RAC3 has been shown to interact and stimulate transcriptional activity of the retinoic acid, retinoid X, vitamin D, mineralocorticoid, glucocorticoid, thyroid hormone, androgen, progesterone, and peroxisome proliferator activated receptors. AIB1:RAC3 also interacts with the transcriptional integrators CREB binding protein (CBP) and p300.
Catalog #A0857-05
Application(s)
Western Blot
Recommended DilutionWestern Blot: Predicted molecular weight: 155kD. Can be blocked with AIB 1 peptide.
Optimal dilution to be determined by the researcher.
Positive ControlT47D cell lysate
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%). Freeze at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in PBS, 1mg/ml BSA, 0.05% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide: GLGENLDPLASDSC, corresponding to amino acids 3-15 of Human AIB 1.
SpecificityDetects human amplified in breast cancer 1 (AIB1). Species Crossreactivity: Expected to crossreact with Xenopus laevis (92% identity with immunogen) due to sequence homology.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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