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You are here:Home » Antibodies » Abs to Matrix Metalloproteinases » Anti -ADAM 10, CT (A Disintegrin And Metalloproteinase 10, MADM, Kuzbanian)

Anti -ADAM 10, CT (A Disintegrin And Metalloproteinase 10, MADM, Kuzbanian)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Highly Purified E B IH
Proinflammatory cytokine tumor necrosis factor-a (TNF-a) contributes to a variety of inflammatory responses and programmed cell death. Notch receptor and its ligand participate in cell fate decisions during vertebrate development and are associated with several human disorders, including a T-cell lymphoma. TNF-a, notch and its ligand delta are all membrane-bond molecules, which are cleaved by proteases to release mature proteins or functional receptor. ADAM10, a metalloprotease-disintegrin in the family of mammalian ADAM (for a disintegrin and metalloprotease), was recently identified to cleave TNF-a, notch and its ligand delta. The genes encoding human, mouse and bovine ADAM10 were recently cloned and designated ADAM 10, kuzbanian (KUZ), and MADM, respectively. ADAM10 mRNA is expressed in a variety of human and bovine tissues.
Catalog #A0859
ApplicationsSuitable for use in Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionsWestern Blot: 1:500-1:2000
Immunohistochemistry: 2ug/ml
Optimal dilution to be determined by the researcher.
Positive ControlJurkat whole cell lysate (85kD band).
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in PBS, 0.02% sodium azide.
PurityPurified by ion-exchange chromatography.
ImmunogenSynthetic peptide corresponding to aa732-748 of human ADAM10.
SpecificityRecognizes human ADAM10 (CT). Species Sequence Homology
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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