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You are here:Home » Antibodies » Abs to Matrix Metalloproteinases » Anti -ADAM 9 (A Disintegrin and Metalloproteinase Domain 9, ADAM Metallopeptidase Domain 9, ADAM9, ADAM-9, Cellular Disintegrin-related Protein, Disintegrin and Metalloproteinase Domain-containing Protein 9, KIAA0021, MDC9, Meltrin gamma, MLTNg, Metalloprotease

Anti -ADAM 9 (A Disintegrin and Metalloproteinase Domain 9, ADAM Metallopeptidase Domain
9, ADAM9, ADAM-9, Cellular Disintegrin-related Protein, Disintegrin and Metalloproteinase
Domain-containing Protein 9, KIAA0021, MDC9, Meltrin gamma, MLTNg, Metalloprotease

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Specifications

Clone Host Grade Applications
Monoclonal Rabbit Supernatant B
The ADAM (A Disintegrin and A Metalloprotease) family of multidomain membrane proteins influences cell signaling and adhesion by shedding cell surface proteins such as cytokines and growth factors, by influencing cell adhesion to the extracellular matrix (ECM), and by directly remodeling the ECM. Conserved domains in ADAM family members include a prodomain, a zinc-dependent metalloprotease domain, a disintegrin domain, a cysteine-rich domain, an EGF-like sequence and a short cytoplasmic tail (1,2).The prodomain is thought to aid in protein folding. Disintegrin and cysteine-rich domains mediate adhesion at least in part through binding to integrins. Phosphorylation of the cytoplasmic tail as well as its interaction with other signaling proteins may influence intra- and extracellular signaling (1). ADAM9 is widely distributed and has been shown to affect migration in skin keratinocytes (3,4). ADAM9 is overexpressed in prostate cancer (5), pancreatic cancer (6), gastric cancer (7) and has been linked to invasion and metastasis in small cell lung cancer (8). An alternatively spliced short (50 kDa) form of ADAM9 containing protease activity is involved in tumor cell invasion (9).
Catalog #A0859-10F
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 1:1000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG
Clone No10g134
HostRabbit
SourceHuman
ConcentrationNot determined.
FormSupplied as a liquid in 10mM sodium HEPES pH 7.5, 150mM NaCl, 0.1mg/ml BSA, < 0.02% sodium azide, 50% glycerol.
PuritySupernatant
ImmunogenSynthetic peptide corresponding to residues near the carboxy terminus of human ADAM9.
SpecificityRecognizes endogenous levels of total human ADAM9 protein. Species crossreactivity: Mouse, rat and monkey.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesEC=3.4.24.-, CORD9, Meltrin-gamma, Metalloprotease/disintegrin/cysteine-rich Protein 9


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