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You are here:Home » Antibodies » Abs to Matrix Metalloproteinases » Anti -ADAM10, CT (Disintegrin and Metalloproteinase Domain-containing Protein 10, ADAM 10, CDw156, Kuzbanian Protein Homolog, Mammalian Disintegrin-metalloprotease, CD156c, KUZ, MADM)

Anti -ADAM10, CT (Disintegrin and Metalloproteinase Domain-containing Protein 10, ADAM 10,
CDw156, Kuzbanian Protein Homolog, Mammalian Disintegrin-metalloprotease, CD156c, KUZ,
MADM)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Purified B IC IF
Cleaves the membrane-bound precursor of TNF-alpha at '76-Ala--Val-77' to its mature soluble form. Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP). Contributes to the normal cleavage of the cellular prion protein. Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity. Controls also the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis.
Catalog #A0859-10P
ApplicationsSuitable for use in Immunofluorescence, Western Blot and Immunocytochemistry. Other applications not tested.
Recommended DilutionImmunofluorescence: 2ug/ml
Western Blot: 1:500-1:2000
Immunocytochemistry: 2ug/ml
Optimal dilutions to be determined by the researcher.
Positive ControlJurkat whole cell lysate.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in PBS, 0.02% sodium azide.
PurityPurified
ImmunogenSynthetic peptide corresponding to human ADAM10.
SpecificityRecognizes human ADAM10.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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