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You are here:Home » Antibodies » Abs to Matrix Metalloproteinases » Anti -ADAM10 (Disintegrin and Metalloproteinase Domain-containing Protein 10, ADAM 10, CDw156, Kuzbanian Protein Homolog, Mammalian Disintegrin-metalloprotease, CD156c, KUZ, MADM)

Anti -ADAM10 (Disintegrin and Metalloproteinase Domain-containing Protein 10, ADAM 10,
CDw156, Kuzbanian Protein Homolog, Mammalian Disintegrin-metalloprotease, CD156c, KUZ,
MADM)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IF
Proinflammatory cytokine tumor necrosis factora (TNF-a) contributes to a variety of inflammatory responses and programmed cell death. Notch receptor and its ligand participate in cell fate decisions during vertebrate development and are associated with several human disorders, including a T-cell lymphoma. TNF-a, notch and its ligand delta are all membrane-bond molecules, which are cleaved by proteases to release mature proteins or functional receptor. ADAM10, a metalloprotease-disintegrin in the family of mammalian ADAM (for a disintegrin and metalloprotease), was recently identified to cleave TNF-a, notch and its ligand delta. The genes encoding human, mouse, and bovine ADAM10 were recently cloned and designated ADAM10, kuzbanian (KUZ), and MADM, respectively. ADAM10 mRNA is expressed in a variety of human and bovine tissues.
Catalog #A0859-10R
ApplicationsSuitable for use in Immunofluorescence and Western Blot. Other applications not tested.
Recommended DilutionImmunofluorescence: 2-10ug/ml
Western Blot: 1-4ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in PBS, pH 7.2, 1% BSA, 0.02% thimerosal, 30% glycerol.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to aa735 from human ADAM10.
SpecificityRecognizes human ADAM10. Species Crossreactivity: rat and bovine.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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