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You are here:Home » Antibodies » Antibodies-Matrix Metalloproteinases » Anti -ADAM 12 (MCMP, MLTN, MLTNA, MCMPMltna, Meltrin alpha, A disintegrin and metalloproteinase domain 12)

Anti -ADAM 12 (MCMP, MLTN, MLTNA, MCMPMltna, Meltrin alpha, A disintegrin and
metalloproteinase domain 12)


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Clone Host Grade Applications
Polyclonal Sheep Affinity Purified E B IP
ADAM12 (A disintegrin and metalloprotease domain 12; also meltrin- ) is a
120kD type I transmembrane glycoprotein member of the metzincin family of
proteases. It is synthesized as a 909 amino acid (aa) preproprecursor that
contains a 25kD proregion (aa 29-207) and a 92kD mature molecule.
Proteolytic cleavage in the Golgi removes the propeptide prior to cell-surface
expression. A 68kD soluble splice form exists in pregnancy where 36 aa
replace the C-terminal 205 aa (705-909). This circulating ADAM12 isoform
remains associated with its prodomain via noncovalent linkage, possibly acting
as an enzyme regulator. Over aa 29-513, human ADAM12 shares 78% and
79% aa identity with bovine and mouse ADAM12, respectively.
Catalog #A0859-25K
ApplicationsSuitable for use in ELISA, Western Blot, and Immunoprecipitation. Other applications not tested.
Recommended DilutionELISA: 0.5-1.0ug/ml
Western Blot: 0.1- 0.2ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityLyophilized powder may be stored at 4°C for short-term only. Reconstitute to nominal volume by adding sterile 40-50% glycerol and store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
FormSupplied as a lyophilized powder in 0.2um sterile-filtered solution in PBS with 5% trehalose. Reconstitute with 40-50% glycerol, PBS.
PurityPurified by immunoaffinity chromatography.
ImmunogenCHO cell-derived, recombinant human ADAM12 aa29-513; O43184 with a Glu36Gln substitution.
SpecificityRecognizes human ADAM12.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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