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You are here:Home » Antibodies » Abs to Matrix Metalloproteinases » Anti -ADAM17 (CD156b, Disintegrin and Metalloproteinase Domain-containing Protein 17, TNF-alpha-converting Enzyme, TNF-alpha Convertase, Snake Venom-like Protease, CSVP, TACE)

Anti -ADAM17 (CD156b, Disintegrin and Metalloproteinase Domain-containing Protein 17,
TNF-alpha-converting Enzyme, TNF-alpha Convertase, Snake Venom-like Protease, CSVP, TACE)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified IH
ADAM17 is a type I transmembrane glycoprotein which belongs to the ADAM (a disintegrin and metalloprotease domain) family. ADAM17 functions as a tumor necrosis factor-alpha converting enzyme (TACE). ADAM17 also causes a number of inflammatory modulators to undergo ectodomain shedding, including TNFR75, IL-1RII, TNFR55, L-selectin, and the amyloid precursor protein among others. ADAM17 plays a prominent role in the activation of the Notch signalling pathway. It also plays a pivotal role in several acquired tumor cell capabilities by mediating the availability of soluble transforming growth factor-alpha, and establishing an autocrine signaling pathway through endogenous EGFR activation. ADAM17 is therefore a prospective therapeutic target in human cancer.
Catalog #A0859-35K
ApplicationsSuitable for use in Immunohistochemistry. Other applications not tested.
Recommended DilutionImmunohistochemistry (paraffin): 20ug/ml
Optimal dilutions to be determined by the researcher.
Positive ControlHuman skeletal muscle
Storage and Stability:
May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile 40-50% glycerol, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in PBS, 0.02% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide sequence corresponding to aa807-823 of human ADAM17.
SpecificityRecognizes human CDADAM17. Species Crossreactivity: mouse, rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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