You are here:Home
»
Antibodies
»
Abs to Matrix Metalloproteinases
»
Anti -ADAM17 (CD156b, Disintegrin and Metalloproteinase Domain-containing Protein 17, TNF-alpha-converting Enzyme, TNF-alpha Convertase, Snake Venom-like Protease, CSVP, TACE)
Anti -ADAM17 (CD156b, Disintegrin and Metalloproteinase Domain-containing Protein 17,
TNF-alpha-converting Enzyme, TNF-alpha Convertase, Snake Venom-like Protease, CSVP, TACE)
Pricing
For pricing information, USA customers sign in. Outside USA? Please contact your distributor for pricing. Specifications
| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
IH |
|
| ADAM17 is a type I transmembrane glycoprotein which belongs to the ADAM (a disintegrin and metalloprotease domain) family. ADAM17 functions as a tumor necrosis factor-alpha converting enzyme (TACE). ADAM17 also causes a number of inflammatory modulators to undergo ectodomain shedding, including TNFR75, IL-1RII, TNFR55, L-selectin, and the amyloid precursor protein among others. ADAM17 plays a prominent role in the activation of the Notch signalling pathway. It also plays a pivotal role in several acquired tumor cell capabilities by mediating the availability of soluble transforming growth factor-alpha, and establishing an autocrine signaling pathway through endogenous EGFR activation. ADAM17 is therefore a prospective therapeutic target in human cancer. | | | Catalog # | A0859-35K | | Applications | Suitable for use in Immunohistochemistry. Other applications not tested. | | Recommended Dilution | Immunohistochemistry (paraffin): 20ug/ml | | Optimal dilutions to be determined by the researcher. | | Positive Control | Human skeletal muscle | | | | Storage and Stability: | | May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile 40-50% glycerol, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Human | | Concentration | ~0.5mg/ml | | Form | Supplied as a liquid in PBS, 0.02% sodium azide. | | Purity | Purified by immunoaffinity chromatography. | | Immunogen | Synthetic peptide sequence corresponding to aa807-823 of human ADAM17. | | Specificity | Recognizes human CDADAM17. Species Crossreactivity: mouse, rat. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
External Links
|
