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You are here:Home » Antibodies » Antibodies-Matrix Metalloproteinases » Anti -ADAM 19 (A Disintegrin And Metalloproteinase 19) (Biotin)

Anti -ADAM 19 (A Disintegrin And Metalloproteinase 19) (Biotin)


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Clone Host Grade Applications
Polyclonal Sheep Affinity Purified B
ADAM19 (a disintegrin and metalloprotease 19; also MADDAM and Meltrin-beta) is a 95-100 kD member of the M12B peptidase family of enzymes. It is expressed on multiple cell types including monocytes, fibroblasts, osteoblasts and dendritic cells. The human ADAM19 proenzyme is a 931 amino acid (aa) type I transmembrane protein. It contains a 178aa cleavable proregion (aa26-203) and a 497 aa extracellular domain (ECD) (aa204-702). The
ECD contains a metalloprotease domain (aa211-409), a disintegrin region (aa417-503) and a Cys-rich domain (aa504-650). The ECD circulates in plasma bound to 700 kD alpha 2-Macroglobulin. One splice variant shows an alternate start site at Met71, while two isoforms show variations afterLys902. Over aa205-702, human ADAM19 is 87% aa identical to mouse ADAM19.
Catalog #A0859-38
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 0.1-0.2ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityLyophilized powder may be stored at 4°C for short-term only. Reconstitute to nominal volume by adding sterile 40-50% glycerol and store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
FormSupplied as a lyophilized powder in 0.2um sterile-filtered solution in PBS with BSA. Reconstitute with 40-50% glycerol, PBS.
PurityPurified by immunoaffinity chromatography.
ImmunogenRecombinant human ADAM19; aa26-501; Q9H013, with a Ser32 deletion and a Lys33Arg substitution.
SpecificityRecognizes human ADAM19.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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