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Anti -ADAM 19 (A Disintegrin And Metalloproteinase 19) (Biotin)
Anti -ADAM 19 (A Disintegrin And Metalloproteinase 19) (Biotin)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Sheep |
Affinity Purified |
B |
|
| ADAM19 (a disintegrin and metalloprotease 19; also MADDAM and Meltrin-beta) is a 95-100 kD member of the M12B peptidase family of enzymes. It is expressed on multiple cell types including monocytes, fibroblasts, osteoblasts and dendritic cells. The human ADAM19 proenzyme is a 931 amino acid (aa) type I transmembrane protein. It contains a 178aa cleavable proregion (aa26-203) and a 497 aa extracellular domain (ECD) (aa204-702). The | | | ECD contains a metalloprotease domain (aa211-409), a disintegrin region (aa417-503) and a Cys-rich domain (aa504-650). The ECD circulates in plasma bound to 700 kD alpha 2-Macroglobulin. One splice variant shows an alternate start site at Met71, while two isoforms show variations afterLys902. Over aa205-702, human ADAM19 is 87% aa identical to mouse ADAM19. | | | Catalog # | A0859-38 | | Applications | Suitable for use in Western Blot. Other applications not tested. | | Recommended Dilution | Western Blot: 0.1-0.2ug/ml | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | Lyophilized powder may be stored at 4°C for short-term only. Reconstitute to nominal volume by adding sterile 40-50% glycerol and store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Sheep | | Source | Human | | Concentration | ~50ug/ml | | Form | Supplied as a lyophilized powder in 0.2um sterile-filtered solution in PBS with BSA. Reconstitute with 40-50% glycerol, PBS. | | | Purity | Purified by immunoaffinity chromatography. | | | Immunogen | Recombinant human ADAM19; aa26-501; Q9H013, with a Ser32 deletion and a Lys33Arg substitution. | | Specificity | Recognizes human ADAM19. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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