| Human ADAM22 is a member of the ADAM (a disintegrin and metalloprotease domain) |
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| family of metalloproteases. Members of this family are membrane-anchored proteins |
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| structurally related to snake venom disintegrins. They have been implicated in a variety of |
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| biological processes involving cell-cell and cell-matrix interactions, such as fertilization, |
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| muscle development, and neurogenesis. ADAM22 is highly expressed in the brain and may |
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| function as an integrin ligand in the brain. The amino acid sequence of human ADAM22 is |
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| 100%, 96% and 92% identical to that of chimpanzee, dog and mouse. |
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| Catalog # | A0859-40J |
| Applications | Suitable for use in ELISA, Western Blot, and Immunoprecipitation. Other applications not tested. |
| Recommended Dilution | ELISA: 0.5-1.0ug/ml |
| Western Blot: 1-2ug/ml |
| Immunoprecipitation: 25ug/ml |
| Optimal dilutions to be determined by the researcher. |
| Storage and Stability | Lyophilized powder may be stored at 4°C for short-term only. Reconstitute to nominal volume by adding sterile 40-50% glycerol and store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. |
| CAS Number | n/a |
| Clone Type | Monoclonal |
| Isotype | IgG2b |
| Clone No | 9H36 |
| Host | Mouse |
| Source | Human |
| Concentration | ~500ug/ml |
| Form | Supplied as a lyophilized powder in PBS, pH 7.2, 0.1% sodium azide. Reconstitute with 40-50% glycerol, PBS. |
| Purity | Purified by Protein G affinity chromatography. |
| Immunogen | CHO-derived, recombinant human ADAM22 aa26-528; Q9POK1. |
| Specificity | Recognizes human ADAM22. |
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| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
