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You are here:Home » Antibodies » Abs to Matrix Metalloproteinases » Anti -ADAM 23 (A Disintegrin And Metalloproteinase 23)

Anti -ADAM 23 (A Disintegrin And Metalloproteinase 23)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified IH
ADAM23 (a disintegrin and metalloprotease domain 23; also MDC3) is a 100kD member of the M12B peptidase family of enzymes. It is expressed on fetal neurons in the hippocampus and cerebellum, and serves as a counter-receptor for alpha v beta 3 integrin. The human ADAM23 proprecursor is a 773aa type I transmembrane (TM) protein. It contains a 227aa cleavable proregion (aa60-286) and a 506aa extracellular domain (ECD) (aa287-792) that is part of a 70kD mature molecule. The ECD contains a nonfunctional metalloprotease domain (aa299-494), an integrin-binding disintegrin region (aa511-585), and a Cys-rich domain (aa589-611). Two splice variants exist. One shows an in-frame 46aa substitution for aa787-832 that generates a soluble form, while a second shows an in-frame 31aaTM substitution for aa787-817. Over aa1-585, human ADAM23 is 92% aa identical to mouse ADAM23.
Catalog #A0859-41D
ApplicationsSuitable for use in Immunohistochemistry. Other applications not tested.
Recommended DilutionImmunohistochemistry: 25ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months after receipt at -20°C. Reconstitute with PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG2a
Clone No9H37
HostMouse
SourceHuman
Concentration~0.5mg/ml (after reconstitution)
FormSupplied as a lyophilized powder in PBS, 5% trehalose. Reconstitute with 200ul PBS.
PurityPurified by Protein G affinity chromatography.
ImmunogenRecombinant protein corresponding to aa60-585 from human ADAM23, CHO-derived (Accession# O75077).
SpecificityRecognizes human ADAM23. Detects recombinant human ADAM23 in direct ELISA’s.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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