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Specifications

Clone Host Grade Applications Monoclonal Mouse Affinity Purified B

Human SH2 domain containing leukocyte protein-76-Associated Phosphoprotein of 130kD (SLAP-130), also known as Fyb-120 and ADAP, is an 86kD, 783 amino acid, cytoplasmic protein that runs anomalously as a 120-130kD protein in SDS-PAGE. Human SLAP-130 is a hematopoietic-specific adaptor that associates with other cytoplasmic proteins such as SH2-containing Leukocyte Phosphoprotein of 76kD (SLP-76). Adaptors integrate signals from surface receptors and are essential components of many immune cell-signaling cascades. There is at least one known alternatively spliced SLAP-130 isoform which contains an additional 46 aa. Over the region used as immunogen, SLAP-130 is 66% and 76% identical to the corresponding canine and mouse proteins, respectively.
Catalog #	A0859-43C
Applications	Suitable for use in Western Blot. Other applications not tested.
Recommended Dilution	Western Blot: 1ug/ml
	Optimal dilutions to be determined by the researcher.
Storage and Stability	Lyophilized powder may be stored at -20°C. Reconstitute to nominal volume by adding sterile 40-50% glycerol, PBS, 01% sodium azide. Aliquot and store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone Type	Monoclonal
Isotype	IgG3
Clone No	8H202
Host	Mouse
Source	Human
Concentration	As reported
Form	Supplied as a lyophilized powder in PBS with 5% trehalose. Reconstitute with 100ul 40-50% glycerol, PBS, 01% sodium azide.
Purity	Purified by Protein G chromatography.
Immunogen	Recombinant human SLAP-130 aa 2-274 (E. coli).
Specificity	Recognizes human SLAP-130.
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.