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You are here:Home » Antibodies » Abs to Matrix Metalloproteinases » Anti -ADAMTS4 (A Disintegrin and Metalloproteinase with Thrombospondin Motifs 4, ADAM-TS 4, ADAM-TS4, ADAMTS-4, ADAMTS-2, ADMP-1, Aggrecanase-1, KIAA0688, UNQ769/PRO1563)

Anti -ADAMTS4 (A Disintegrin and Metalloproteinase with Thrombospondin Motifs 4, ADAM-TS
4, ADAM-TS4, ADAMTS-4, ADAMTS-2, ADMP-1, Aggrecanase-1, KIAA0688, UNQ769/PRO1563)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified IH
ADAMTS4, also known as aggrecanase-1, is a Metallopeptidase M12B type protease that is responsible for degradation of the articular cartilage protein aggrecan and the brain extracellular matrix proteoglycan brevican. The ADAMTS4 protein contains a signal sequence, a propeptide domain, a catalytic domain, a disintegrin-like motif, and a C-terminal domain with a thrombospondin (TSP) type 1 motif. ADAMTS4 has been implicated in inflammatory joint diseases, and it also may be a factor in the progression of glioma and Alzheimer's disease. ADAMTS4 expression has been documented in normal Human brain, cartilage, heart, lung, placenta, muscle, and synovium. ESTs have been isolated from Human tissue libraries, including normal brain, lung, pancreas, and skeletal muscle and cancerous breast.
Catalog #A0859-60S
ApplicationsSuitable for use in Immunohistochemistry. Other applications not tested.
Recommended DilutionImmunohistochemistry (paraffin): 2.5-20ug/ml
Optimal dilutions to be determined by the researcher.
Positive ControlHuman Cartilage
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in PBS, pH 7.7, 0.01% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to the Disintegrin-like domain of human ADAMTS4.
SpecificityRecognizes human ADAMTS4.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesADAM Metallopeptidase with Thrombospondin Type 1 Motif, 4, EC=3.4.24.82


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